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News and Updates
A research team funded by the National Institutes of Health has shown that commercially available rapid antigen tests can detect past and present
9/19/2022
NIH Rapid Acceleration of Diagnostics (RADx®) Tech program (9/19/2022)

A research team funded by the National Institutes of Health has shown that commercially available rapid antigen tests can detect past and presen...

Researchers from the National Eye Institute (NEI) have developed a gene therapy that rescues cilia defects in retinal cells affected by a type of Leber congenital amaurosis (LCA), a disease that causes blindness in early childhood. Using patient-derived retina organoids (also known as retinas-in-a-dish), the researchers discovered that a type of LCA caused by mutations in the NPHP5 (also called IQCB1) gene leads to severe defects in the primary cilium, a structure found in nearly all cells of the body. The findings not only shed light on the function of NPHP5 protein in the primary cilium, but also led to a potential treatment for this blinding condition. NEI is part of the National Institutes of Health.
9/12/2022
NIH researchers develop gene therapy for rare ciliopathy (9/12/2022)

Researchers from the National Eye Institute (NEI) have developed a gene therapy that rescues cilia defects in retinal cells affected by a type of Lebe...

A clinical trial evaluating alternative strategies for administering the JYNNEOS monkeypox vaccine to increase the number of available doses has begun enrolling adult volunteers. The trial, which will enroll more than 200 adults across eight U.S. research sites, is sponsored by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health. JYNNEOS is manufactured by Bavarian Nordic, based in Copenhagen. It is approved by the U.S. Food and Drug Administration for the prevention of smallpox and monkeypox disease in adults 18 years of age and older determined to be at high risk for smallpox or monkeypox infection.
9/12/2022
Clinical Trial Evaluating Monkeypox Vaccine Begins (9/12/2022)

A clinical trial evaluating alternative strategies for administering the JYNNEOS monkeypox vaccine to increase the number of available doses has begun...

A Phase 3 clinical trial evaluating the antiviral tecovirimat, also known as TPOXX, is now enrolling adults and children with monkeypox infection in the United States. Study investigators aim to enroll more than 500 people from clinical research sites nationwide. Interested volunteers can visit the ACTG website (clinical trial A5418)(link is external) for more information. The trial is sponsored by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health. The NIAID-funded AIDS Clinical Trials Group(link is external) (ACTG) is leading the study, which may later expand to international sites. The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) at NIH is supporting several sites, including through the International Maternal Pediatric Adolescent AIDS Clinical Trials Network (IMPAACT).
9/12/2022
U.S. clinical trial evaluating antiviral for monkeypox begins (9/12/2022)

A Phase 3 clinical trial evaluating the antiviral tecovirimat, also known as TPOXX, is now enrolling adults and children with monkeypox infection in t...

The National Institutes of Health has issued two new funding opportunities for diagnostic test manufacturers to develop the next generation of COVID-19 tests, with a major focus on accessibility. The funding opportunities are part of the Rapid Acceleration of Diagnostics (RADx) Tech program, managed by the National Institute of Biomedical Imaging and Bioengineering (NIBIB). The new programs may award up to $300 million in funds from the American Rescue Plan Act of 2021 to support the accelerated development of tests and provide regulatory guidance during the COVID-19 pandemic and beyond.
9/12/2022
NIH seeks the next generation of COVID-19 diagnostics (9/12/2022)

The National Institutes of Health has issued two new funding opportunities for diagnostic test manufacturers to develop the next generation of COVID-1...

A clinical trial evaluating alternative strategies for administering the JYNNEOS monkeypox vaccine to increase the number of available doses has begun enrolling adult volunteers. The trial, which will enroll more than 200 adults across eight U.S. research sites, is sponsored by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health. JYNNEOS is manufactured by Bavarian Nordic, based in Copenhagen. It is approved by the U.S. Food and Drug Administration for the prevention of smallpox and monkeypox disease in adults 18 years of age and older determined to be at high risk for smallpox or monkeypox infection.
9/12/2022
Clinical Trial Evaluating Monkeypox Vaccine Begins (9/12/2022)

A clinical trial evaluating alternative strategies for administering the JYNNEOS monkeypox vaccine to increase the number of available doses has begun...

A treatment to move blood from the umbilical cord into an infant’s body may improve the overall health of newborns classified as non-vigorous—limp, pale and with minimal breathing, suggests a study funded by the National Institutes of Health. The procedure, known as umbilical cord milking, involves gently squeezing the cord between the thumb and forefinger and slowly pushing the blood into the abdomen. Compared to non-vigorous infants receiving the standard treatment of immediate umbilical cord clamping, infants who underwent cord milking were less likely to need heart and respiratory support, less likely to have a low level of oxygen in the brain, and more likely to have higher levels of hemoglobin, a substance indicating the presence of red blood cells.
9/12/2022
Umbilical cord milking may improve health in non-vigorous term and near-term infants (9/12/2022)

A treatment to move blood from the umbilical cord into an infant’s body may improve the overall health of newborns classified as non-vigorous—limp, pa...

The Centers for Disease Control and Prevention (CDC) has recommended that Novavax’s COVID-19 vaccine be used as another primary series option for adults in the United States ages 18 years and older. The Food and Drug Administration (FDA) previously authorized for emergency use the protein-based vaccine, known as NVX-CoV2373.
7/27/2022
Statement from NIH and BARDA on the Novavax COVID-19 Vaccine (7/27/2022)

The Centers for Disease Control and Prevention (CDC) has recommended that Novavax’s COVID-19 vaccine be used as another primary series option for adul...

NIH-funded clinical trial finds that starting with a cheaper drug and switching to a more expensive drug as needed leads to good vision outcomes in diabetic macular edema.
7/27/2022
Cardiovascular-related deaths in the U.S. fall, but disparities remain (7/27/2022)

NIH-funded clinical trial finds that starting with a cheaper drug and switching to a more expensive drug as needed leads to good vision outcomes in di...

Loss of the protein pigment epithelium-derived factor (PEDF), which protects retinal support cells, may drive age-related changes in the retina, according to a new study in mice from the National Eye Institute (NEI). The retina is the light-sensitive tissue at the back of the eye, and aging-associated diseases of the retina, like age-related macular degeneration (AMD), can lead to blindness. This new finding could lead to therapies to prevent AMD and other aging conditions of the retina. The study was published in the International Journal of Molecular Sciences. NEI is part of the National Institutes of Health.
7/27/2022
NIH study finds loss of ‘youth’ protein may drive aging in the eye (7/27/2022)

Loss of the protein pigment epithelium-derived factor (PEDF), which protects retinal support cells, may drive age-related changes in the retina, accor...

Although COVID-19 booster vaccinations in adults elicit high levels of neutralizing antibodies against the Omicron variant of SARS-CoV-2, antibody levels decrease substantially within 3 months, according to new clinical trial data. The findings, published today in Cell Reports Medicine, are from a study sponsored by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health. The trial was led by NIAID’s Infectious Diseases Clinical Research Consortium.
7/27/2022
Vaccine-Induced Immune Response to Omicron Wanes Substantially Over Time (7/27/2022)

Although COVID-19 booster vaccinations in adults elicit high levels of neutralizing antibodies against the Omicron variant of SARS-CoV-2, antibody lev...

Research supported by the National Institutes of Health shows that cardiovascular-related deaths have declined over the past two decades, but disparities remain. Researchers found that inequities are mostly driven by differences in race and ethnicity, geographic location, and access to care, among other factors. The findings were published in Circulation, and the research was partially funded by the National Heart, Lung, and Blood Institute (NHLBI), part of NIH.
7/27/2022
Cardiovascular-related deaths in the U.S. fall, but disparities remain (7/27/2022)

Research supported by the National Institutes of Health shows that cardiovascular-related deaths have declined over the past two decades, but disparit...

A class of viruses known to cause severe diarrheal diseases – including the one famous for widespread outbreaks on cruise ships – can grow in the salivary glands of mice and spread through their saliva, scientists at the National Institutes of Health have discovered. The findings show that a new route of transmission exists for these common viruses, which afflict billions of people each year worldwide and can be deadly.
7/8/2022
NIH scientists discover norovirus and other “stomach viruses” can spread through saliva (7/8/2022)

A class of viruses known to cause severe diarrheal diseases – including the one famous for widespread outbreaks on cruise ships – can grow in the sali...

An international team of scientists has identified the neural mechanisms through which sound blunts pain in mice. The findings, which could inform development of safer methods to treat pain, were published in Science. The study was led by researchers at the National Institute of Dental and Craniofacial Research (NIDCR); the University of Science and Technology of China, Hefei; and Anhui Medical University, Hefei, China. NIDCR is part of the National Institutes of Health.
7/8/2022
Researchers discover how sound reduces pain in mice (7/8/2022)

An international team of scientists has identified the neural mechanisms through which sound blunts pain in mice. The findings, which could inform dev...

The eye’s light-sensing retina taps different circuits depending on whether it is generating image-forming vision or carrying out a non-vision function such as regulating pupil size or sleep/wake cycles, according to a new mouse study from the National Eye Institute (NEI) and the National Institute of Mental Health (NIMH). The findings could have implications for understanding how our eyes help regulate mood, digestion, sleep, and metabolism. NEI and NIMH are part of the National Institutes of Health.
7/8/2022
NIH researchers decode retinal circuits for circadian rhythm, pupillary light response (7/8/2022)

The eye’s light-sensing retina taps different circuits depending on whether it is generating image-forming vision or carrying out a non-vision functio...

A study from the National Institutes of Health describes the immune response triggered by COVID-19 infection that damages the brain’s blood vessels and may lead to short- and long-term neurological symptoms. In a study published in Brain, researchers from the National Institute of Neurological Disorders and Stroke (NINDS) examined brain changes in nine people who died suddenly after contracting the virus.
7/8/2022
Small NIH study reveals how immune response triggered by COVID-19 may damage the brain (7/8/2022)

A study from the National Institutes of Health describes the immune response triggered by COVID-19 infection that damages the brain’s blood vessels an...

COVID-19 was the third leading cause of death in the United States between March 2020 and October 2021, according to an analysis of national death certificate data by researchers at the National Cancer Institute, part of the National Institutes of Health. The study appears July 5 in JAMA Internal Medicine.
7/8/2022
COVID-19 was third leading cause of death in the United States in both 2020 and 2021 (7/8/2022)

COVID-19 was the third leading cause of death in the United States between March 2020 and October 2021, according to an analysis of national death cer...

Early Stage Testing of Pharmacologic or Device-based Interventions for the Treatment of Mental Disorders Click here to read more
1/18/2022
Early Stage Testing of Pharmacologic or Device-based Interventions for the Treatment of Mental Disorders (1/18/2022)

Early Stage Testing of Pharmacologic or Device-based Interventions for the Treatment of Mental Disorders

Innovative ways to provide education on antimicrobial stewardship practices in animals Click here to read more
1/18/2022
Innovative ways to provide education on antimicrobial stewardship practices in animals (U01) Clinical Trial Not Allowed (1/18/2022)

Innovative ways to provide education on antimicrobial stewardship practices in animals

Notice of Information: Temporary Extension of Eligibility for NHLBI K24 Applicants Due to COVID-19 Click here to read more
1/18/2022
Notice of Information: Temporary Extension of Eligibility for NHLBI K24 Applicants Due to COVID-19 (1/18/2022)

Notice of Information: Temporary Extension of Eligibility for NHLBI K24 Applicants Due to COVID-19

Coordinating Center for the HIV/AIDS and Substance Use Cohorts Program (U24 - Clinical Trial Not Allowed) Click here to read more
1/13/2022
Coordinating Center for the HIV/AIDS and Substance Use Cohorts Program (U24 - Clinical Trial Not Allowed) (1/13/2022)

Coordinating Center for the HIV/AIDS and Substance Use Cohorts Program (U24 - Clinical Trial Not Allowed)

Notice of change to key dates for RFA-MH-22-120: Pilot Practice-based Research for Primary Care Suicide Prevention (R34 Clinical Trial Optional) Click here to read more
1/13/2022
Notice of change to key dates for RFA-MH-22-120:Pilot Practice-based Research for Primary Care Suicide Prevention (R34 Clinical Trial Optional) (1/13/2022)

Notice of change to key dates for RFA-MH-22-120: Pilot Practice-based Research for Primary Care Suicide Prevention (R34 Clinical Trial Optional)

Notice of Participation of the National Center for Complementary and Integrative Health (NCCIH) in RFA-EY-21-003, BRAIN Initiative-Related Research Education: Short Courses (R25 Clinical Trial Not Allowed) Click here to read more
1/13/2022
BRAIN Initiative-Related Research Education: Short Courses (R25 Clinical Trial Not Allowed) (1/13/2022)

Notice of Participation of the National Center for Complementary and Integrative Health (NCCIH) in RFA-EY-21-003, BRAIN Initiative-Related Research Ed...

Inviting Comments and Suggestions on the Draft NIH Chief Officer for Scientific Workforce Diversity Strategic Plan for FYs 2022-2026 Click here to read more
1/13/2022
Inviting Comments and Suggestions on the Draft NIH Chief Officer for Scientific Workforce Diversity Strategic Plan for FYs 2022-2026 (1/13/2022)

Inviting Comments and Suggestions on the Draft NIH Chief Officer for Scientific Workforce Diversity Strategic Plan for FYs 2022-2026

Using a stem-cell-derived model, researchers have identified two drug candidates that may slow dry age-related macular degeneration (AMD) Click here to read more
12/15/2021
NIH researchers identify potential AMD drugs with stem-cell based research tool (12/15/2021)

Using a stem-cell-derived model, researchers have identified two drug candidates that may slow dry age-related macular degeneration (AMD)


NaviGRANT Stats
Total Grants1,550,730
Current Grants175,982
Total Awarded for Current Grants$96.4 billion
Added in Last 30 Days9,406
Total Sources102
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